There is a discrepancy in the Gleason score given on the initial biopsy and prostatectomy specimen, respectively, that affects both patients who can benefit from active surveillance and those who cannot benefit from curative surgical treatment, and for whom therapeutic alternatives must be established.
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In this context, our study aimed at analyzing the diagnostic concordance between biopsies and subsequent prostatectomies, in order to establish the accuracy of prostate biopsy in predicting final Gleason score of the prostatectomy specimens. Material and methods: We analyzed 79 cases of PADK, initially diagnosed by prostate biopsy and subsequently treated by radical prostatectomy. The accuracy degree of the tumoral grading system assigned to the prostate biopsy, compared with the radical prostatectomy, was assessed by predicting prostate cancer of the Cohen's kappa concordance coefficient and calculation of sensitivity, specificity, positive prognostic value and negative prognostic value.
Results: 37 cases In prostate biopsies, 32 cases The lowest agreement rate was predicting prostate predicting prostate cancer for Gleason score 5, where no case showed a similar score for biopsy and prostatectomy.
Statistical analysis indicated a kappa coefficient of 0. The agreement on ISUP prognostic grade groups between prostate biopsy and radical prostatectomy indicated a slight increase in kappa coefficient Conclusions: Our results demonstrate an increase in the predictive accuracy of prostate biopsy, as a result of the application of prognostic grade group system, which ensure the decrease of overestimating tendency of the old scoring system, ultimately leading to a preliminary characterization of potential lesions in prostatectomy specimens and a predicting prostate cancer effective treatment stratification of patients.
Author Biographies A. Lyon: International Agency for Research on Cancer, A contemporary prostate cancer grading system: A vali-dated alternative to the Gleason score.
Since that time, new data have become available, these have been incorporated into the Monograph, and taken into consideration in the present evaluation. Exposure Data 1. Types and ethanol content of alcoholic beverages 1. Types of alcoholic beverages The predominant types of commercially produced alcoholic beverages are beer, wine and spirits.
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Mol Clin Oncol ; 2 6 : J Clin Oncol ; 34 18 : Front Med Lausanne ; 4: Prostate cancer grading: a decade after the modified system. Mod Pathol ; 31 S1 : SS Grignon DJ. Prostate cancer reporting and staging: needle biopsy and radical prostatectomy specimens.
Preoperative prediction of Gleason grade in radical prostatectomy specimens: the influence of different Gleason grades from multiple positive biopsy sites.
Mod Pathol ; 18 2 : Evaluation of concordance of Gleason score between prostatectomy and biopsies that show more than two different Gleason scores in positive cores.
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Urology ; 67 1 : Multiple prostate cancer cores with different Gleason grades submitted in the same specimen container without specific site designation: should each core be assigned an individual Gleason score? Hum Pathol ; 40 4 : Should intervening benign tissue be included in the meas-urement of discontinuous foci of cancer on prostate needle biopsy? Correlation with radical prostatec-tomy findings. Am J Surg Pathol ; 35 9 : Continuous versus discontinuous tumor involvement: A di-lemma in prostate biopsy quantitation.
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J Urol ; 2 : A critical evaluation of visual proportion of Gleason 4 and maximum cancer core length quantified by histopathologists. Inter-observer variability of cribriform archi-tecture and percent Gleason pattern 4 in prostate cancer: relation to clinical predicting prostate cancer. Virchows Arch ; 2 : Gleason pattern 4 with cribriform morphology on biopsy is associated with adverse clinicopathological findings in a prospective radical prostatectomy cohort.
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Concordance between Gleason scores of needle biopsies and radical prostatectomy specimens: A population-based study. BJU Int ; 12 : Gleason score and laterality concordance between prostate biopsy and prostatectomy specimens.
Predictive Models for Optimizing Imaging Decisions for Detection of Metastatic Prostate Cancer
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Gleason group concordance between biopsy and radical prostatectomy specimens: A cohort study from Prostate Cancer Outcome Registry -Victoria. Prostate Int ; 4 4 :
But flight designers came up with a daring plan to reduce the risk. Dar designerii de zbor, au venit cu un plan îndrăzneț, pentru a reduce riscul. Washing your hands frequently you will reduce the risk of bacteria and viruses being transmitted to you. Spălat mâinile frecvent va reduce riscul de bacteriile si virusii se transmit la tine. We analyze human behavior in order to predict performance and reduce the risk of accident.