Tumor volume prostate cancer, Value of ultrasound elastography in the diagnosis and management of prostate carcinoma.


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There is a discrepancy in the Gleason score given tumor volume prostate cancer the initial biopsy and prostatectomy specimen, respectively, that affects both patients who can benefit from active surveillance and those who cannot benefit from curative surgical treatment, and for whom therapeutic alternatives must be established. In this context, our study aimed at analyzing the diagnostic concordance between biopsies and subsequent prostatectomies, in order to establish the accuracy of prostate biopsy in predicting final Gleason score of the prostatectomy specimens.

Material and methods: We analyzed 79 cases of PADK, initially diagnosed by prostate biopsy and subsequently treated by radical prostatectomy.

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The accuracy degree of the tumoral grading system tumor volume prostate cancer to the prostate biopsy, compared with the radical prostatectomy, was assessed by calculation of the Cohen's kappa concordance coefficient and calculation of sensitivity, specificity, positive prognostic value and negative prognostic value.

Results: 37 cases In prostate biopsies, 32 cases The lowest agreement rate was observed for Gleason score 5, where no case showed a similar score for biopsy and prostatectomy. Statistical analysis indicated a kappa coefficient of 0.

It has the potential to reduce false negatives and speed up diagnosis, which can make a life-saving difference to patients. Prostate biopsy, the most reliable method of detection, is a challenge because of the difficulties in visualizing not only the entirety of the prostate, but also the location of the biopsy needle. Trans-rectal ultrasound-guided prostate biopsy TRUSthe current biopsy standard, commonly suffers from poor image resolution, and the biopsy needle often passes through tumor-free areas of the prostate — potentially missing the tumor entirely.

The agreement on ISUP prognostic grade groups between prostate biopsy and radical prostatectomy indicated a slight increase in kappa coefficient Conclusions: Our results demonstrate an increase in the predictive accuracy of prostate biopsy, as a result of the application of prognostic grade group system, which ensure the decrease of overestimating tendency of the old scoring system, ultimately leading to a preliminary characterization of potential lesions in prostatectomy specimens and a more effective treatment stratification of patients.

Author Biographies A. Lyon: International Agency for Research on Cancer, A contemporary prostate cancer grading system: A vali-dated alternative to the Gleason score.

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Adăugați în lista de dorințe Instalați Traduceți descrierea în română folosind Google Traducere? Traduceți descrierea înapoi în engleză Statele Unite ale Americii Traduceți "Urology Prostate Calculator: Volume and Density" app is designed to help health professional to assess patients with prostate enlargement BPH or prostate cancer. Tumor volume is used, along with the Gleason Score, to prognosticate prostate cancer recurrence. PSA density helps distinguish between BPH and prostate cancer and determine the need for prostate biopsy.

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Multiparametric Magnetic Resonance Imaging in prostate cancer diagnosis: a must

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Inter-observer variability of cribriform archi-tecture and percent Gleason pattern 4 in prostate cancer: relation to clinical outcome.

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Concordance between Gleason scores of needle biopsies and radical prostatectomy specimens: A population-based study.

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Value of ultrasound elastography in the diagnosis and management of prostate carcinoma.

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